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recombinant mouse osteocalcin  (Cusabio)


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    Cusabio recombinant mouse osteocalcin
    Recombinant Mouse Osteocalcin, supplied by Cusabio, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+mouse+osteocalcin/Recombinant+Mouse+Osteocalcin/pm35296883-240-0-3
    Average 92 stars, based on 3 article reviews
    recombinant mouse osteocalcin - by Bioz Stars, 2026-09
    92/100 stars

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    Related Articles

    Recombinant:

    Article Title: Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
    Article Snippet: .. Recombinant mouse osteocalcin (Cusabio; MBS948782) in the dose of 0.03 μg/h administered continuously to female C57Bl6J mice ( n = 8/group) via Alzet osmotic mini pumps. ..

    Article Title: Leptin induces osteocalcin expression in ATDC5 cells through activation of the MAPK-ERK1/2 signaling pathway
    Article Snippet: Recombinant mouse leptin was obtained from R&D. .. Recombinant mouse osteocalcin was obtained from Cusabio. ..

    Article Title: Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males.
    Article Snippet: Liubov S. Kalinichenko1, Christiane Mühle1, Tianye Jia 2,3, Felix Anderheiden1, Maria Datz1, Anna-Lisa Eberle1, Volker Eulenburg4, Jonas Granzow1, Martin Hofer1, Julia Hohenschild1, Sabine E. Huber1, Stefanie Kämpf1, Georgios Kogias1, Laura Lacatusu1, Charlotte Lugmair1, Stephen Mbu Taku1, Doris Meixner1, Nina-Kristin Sembritzki1, Marc Praetner1,5, Cosima Rhein1,6, Christina Sauer1, Jessica Scholz1, Franziska Ulrich1, Florian Valenta1, Esther Weigand1, Markus Werner1, Nicole Tay2, Conor J. Mc Veigh7, Jana Haase7, An-Li Wang8, Laila Abdel-Hafiz8, Joseph P. Huston8, Irena Smaga9, Malgorzata Frankowska9, Malgorzata Filip9, Anbarasu Lourdusamy10, Philipp Kirchner11, Arif B. Ekici11, Lena M. Marx1, Neeraja Puliparambil Suresh1, Renato Frischknecht12, Anna Fejtova1, Essa M. Saied13,14, Christoph Arenz13, Aline Bozec15,16, Isabel Wank17, Silke Kreitz17, Andreas Hess17, Tobias Bäuerle18, Maria Dolores Ledesma19, Daniel N. Mitroi19, André M. Miranda20,21, Tiago Gil Oliveira20,21, Bernd Lenz1,22, Gunter Schumann2,3,23,†, Johannes Kornhuber1,†, Christian P. Müller *

    Mouse Assay:

    Article Title: Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
    Article Snippet: .. Recombinant mouse osteocalcin (Cusabio; MBS948782) in the dose of 0.03 μg/h administered continuously to female C57Bl6J mice ( n = 8/group) via Alzet osmotic mini pumps. ..



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    csOCN ameliorated OA/PA-induced lipid accumulation in hepatocytes. ( A ) Amino acid sequence of mouse <t>osteocalcin.</t> ( B ) TG accumulation in NCTC 1469 cells was assessed according to the instructions of the Triglyceride Content Assay Kit (BC0625, Solarbio). ( C ) Representative photomicrographs of Oil Red O staining, Nile Red staining and BODIPY 493/503 staining (200×). ( D ) Absorbance analysis of Oil Red O dye after elution with isopropanol. ( E ) Mean fluorescence intensity of Nile Red staining in Fig. 1C. ( F ) Mean fluorescence intensity of BODIPY 493/503 staining in Fig. 1C. The data are presented as the means ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. OA/PA, oleic acid, and palmitic acid; csOCN, oleic acid, and palmitic acid + chemically synthesized osteocalcin; GluOC, OA/PA + uncarboxylated osteocalcin
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    csOCN ameliorated OA/PA-induced lipid accumulation in hepatocytes. ( A ) Amino acid sequence of mouse <t>osteocalcin.</t> ( B ) TG accumulation in NCTC 1469 cells was assessed according to the instructions of the Triglyceride Content Assay Kit (BC0625, Solarbio). ( C ) Representative photomicrographs of Oil Red O staining, Nile Red staining and BODIPY 493/503 staining (200×). ( D ) Absorbance analysis of Oil Red O dye after elution with isopropanol. ( E ) Mean fluorescence intensity of Nile Red staining in Fig. 1C. ( F ) Mean fluorescence intensity of BODIPY 493/503 staining in Fig. 1C. The data are presented as the means ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. OA/PA, oleic acid, and palmitic acid; csOCN, oleic acid, and palmitic acid + chemically synthesized osteocalcin; GluOC, OA/PA + uncarboxylated osteocalcin
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    recombinant mouse osteocalcin  (Cusabio)
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    Cusabio recombinant mouse osteocalcin
    csOCN ameliorated OA/PA-induced lipid accumulation in hepatocytes. ( A ) Amino acid sequence of mouse <t>osteocalcin.</t> ( B ) TG accumulation in NCTC 1469 cells was assessed according to the instructions of the Triglyceride Content Assay Kit (BC0625, Solarbio). ( C ) Representative photomicrographs of Oil Red O staining, Nile Red staining and BODIPY 493/503 staining (200×). ( D ) Absorbance analysis of Oil Red O dye after elution with isopropanol. ( E ) Mean fluorescence intensity of Nile Red staining in Fig. 1C. ( F ) Mean fluorescence intensity of BODIPY 493/503 staining in Fig. 1C. The data are presented as the means ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. OA/PA, oleic acid, and palmitic acid; csOCN, oleic acid, and palmitic acid + chemically synthesized osteocalcin; GluOC, OA/PA + uncarboxylated osteocalcin
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    Image Search Results


    csOCN ameliorated OA/PA-induced lipid accumulation in hepatocytes. ( A ) Amino acid sequence of mouse osteocalcin. ( B ) TG accumulation in NCTC 1469 cells was assessed according to the instructions of the Triglyceride Content Assay Kit (BC0625, Solarbio). ( C ) Representative photomicrographs of Oil Red O staining, Nile Red staining and BODIPY 493/503 staining (200×). ( D ) Absorbance analysis of Oil Red O dye after elution with isopropanol. ( E ) Mean fluorescence intensity of Nile Red staining in Fig. 1C. ( F ) Mean fluorescence intensity of BODIPY 493/503 staining in Fig. 1C. The data are presented as the means ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. OA/PA, oleic acid, and palmitic acid; csOCN, oleic acid, and palmitic acid + chemically synthesized osteocalcin; GluOC, OA/PA + uncarboxylated osteocalcin

    Journal: Journal of Translational Medicine

    Article Title: Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway

    doi: 10.1186/s12967-024-05592-y

    Figure Lengend Snippet: csOCN ameliorated OA/PA-induced lipid accumulation in hepatocytes. ( A ) Amino acid sequence of mouse osteocalcin. ( B ) TG accumulation in NCTC 1469 cells was assessed according to the instructions of the Triglyceride Content Assay Kit (BC0625, Solarbio). ( C ) Representative photomicrographs of Oil Red O staining, Nile Red staining and BODIPY 493/503 staining (200×). ( D ) Absorbance analysis of Oil Red O dye after elution with isopropanol. ( E ) Mean fluorescence intensity of Nile Red staining in Fig. 1C. ( F ) Mean fluorescence intensity of BODIPY 493/503 staining in Fig. 1C. The data are presented as the means ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. OA/PA, oleic acid, and palmitic acid; csOCN, oleic acid, and palmitic acid + chemically synthesized osteocalcin; GluOC, OA/PA + uncarboxylated osteocalcin

    Article Snippet: We constructed a recombinant mouse GST-osteocalcin fusion protein and used DE3 (TransGen Biotech, China) to express the reconstructed GluOC. csOCN was purchased from Sangon Biotech, and it is a chemical synthesis of mouse osteocalcin (46 aa) with a C19-C25 disulfide bond modification.

    Techniques: Sequencing, Staining, Fluorescence, Synthesized

    csOCN attenuates lipid accumulation in NCTC 1469 cells via CD36. ( A ) siRNA-CD36-1136, siRNA-CD36-1300, and siRNA-CD36-1624 all significantly suppressed CD36 mRNA expression. The data are presented as the means ± SD of six independent experiments. **** p < 0.0001 versus the si-NC group. ( B ) Protein expression of CD36 after transfection. ( C ) csOCN treatment and CD36 knockdown reduced TG levels in the NCTC 1469 cells exposed to OA/PA. ( D ) Oil red O staining and BODIPY 493/503 staining showed that csOCN treatment and CD36 knockdown reduced lipid accumulation in NCTC 1469 cells exposed to OA/PA (200×). ( E ) Absorbance analysis of the Oil red O dye after isopropanol elution. ( F ) The mean fluorescence intensity of BODIPY 493/503 staining in Fig. 3C. The data are presented as the means ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001. Control + si-NC, Control + siRNA-negative control; Control + si-CD36, Control + siRNA-CD36; OA/PA + si-CD36, oleic acid and palmitic acid + siRNA-CD36; OA/PA + si-NC, oleic acid and palmitic acid + siRNA-negative control; OA/PA + si-NC + csOCN, oleic acid and palmitic acid + siRNA-negative control + chemically synthesized osteocalcin

    Journal: Journal of Translational Medicine

    Article Title: Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway

    doi: 10.1186/s12967-024-05592-y

    Figure Lengend Snippet: csOCN attenuates lipid accumulation in NCTC 1469 cells via CD36. ( A ) siRNA-CD36-1136, siRNA-CD36-1300, and siRNA-CD36-1624 all significantly suppressed CD36 mRNA expression. The data are presented as the means ± SD of six independent experiments. **** p < 0.0001 versus the si-NC group. ( B ) Protein expression of CD36 after transfection. ( C ) csOCN treatment and CD36 knockdown reduced TG levels in the NCTC 1469 cells exposed to OA/PA. ( D ) Oil red O staining and BODIPY 493/503 staining showed that csOCN treatment and CD36 knockdown reduced lipid accumulation in NCTC 1469 cells exposed to OA/PA (200×). ( E ) Absorbance analysis of the Oil red O dye after isopropanol elution. ( F ) The mean fluorescence intensity of BODIPY 493/503 staining in Fig. 3C. The data are presented as the means ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001. Control + si-NC, Control + siRNA-negative control; Control + si-CD36, Control + siRNA-CD36; OA/PA + si-CD36, oleic acid and palmitic acid + siRNA-CD36; OA/PA + si-NC, oleic acid and palmitic acid + siRNA-negative control; OA/PA + si-NC + csOCN, oleic acid and palmitic acid + siRNA-negative control + chemically synthesized osteocalcin

    Article Snippet: We constructed a recombinant mouse GST-osteocalcin fusion protein and used DE3 (TransGen Biotech, China) to express the reconstructed GluOC. csOCN was purchased from Sangon Biotech, and it is a chemical synthesis of mouse osteocalcin (46 aa) with a C19-C25 disulfide bond modification.

    Techniques: Expressing, Transfection, Knockdown, Staining, Fluorescence, Control, Negative Control, Synthesized

    Computer simulation to analyze the effects of osteocalcin, oleic acid and palmitic acid on CD36. ( A ) Binding mode of CD36 and osteocalcin complexes, with a general view on the left and interaction details on the right. The CD36 protein is shown in blue, and osteocalcin is shown in wheat. The yellow dashed lines indicate hydrogen bond interactions, and the burgundy dashed lines indicate salt bridge interactions. Binding patterns of oleic acid ( B ) and palmitic acid ( C ) to CD36. The left figure shows the total view, and the right figure shows the partial view. The orange bar is the small molecule, and the light blue cartoon is the protein. The blue line indicates hydrogen bonding, the gray dashed line indicates hydrophobicity and the yellow dashed line indicates salt bridge interactions. ( D ) Spatial distribution of osteocalcin, oleic acid and palmitic acid bound to the cell membrane of CD36

    Journal: Journal of Translational Medicine

    Article Title: Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway

    doi: 10.1186/s12967-024-05592-y

    Figure Lengend Snippet: Computer simulation to analyze the effects of osteocalcin, oleic acid and palmitic acid on CD36. ( A ) Binding mode of CD36 and osteocalcin complexes, with a general view on the left and interaction details on the right. The CD36 protein is shown in blue, and osteocalcin is shown in wheat. The yellow dashed lines indicate hydrogen bond interactions, and the burgundy dashed lines indicate salt bridge interactions. Binding patterns of oleic acid ( B ) and palmitic acid ( C ) to CD36. The left figure shows the total view, and the right figure shows the partial view. The orange bar is the small molecule, and the light blue cartoon is the protein. The blue line indicates hydrogen bonding, the gray dashed line indicates hydrophobicity and the yellow dashed line indicates salt bridge interactions. ( D ) Spatial distribution of osteocalcin, oleic acid and palmitic acid bound to the cell membrane of CD36

    Article Snippet: We constructed a recombinant mouse GST-osteocalcin fusion protein and used DE3 (TransGen Biotech, China) to express the reconstructed GluOC. csOCN was purchased from Sangon Biotech, and it is a chemical synthesis of mouse osteocalcin (46 aa) with a C19-C25 disulfide bond modification.

    Techniques: Binding Assay, Membrane

    Interaction types of osteocalcin and CD36

    Journal: Journal of Translational Medicine

    Article Title: Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway

    doi: 10.1186/s12967-024-05592-y

    Figure Lengend Snippet: Interaction types of osteocalcin and CD36

    Article Snippet: We constructed a recombinant mouse GST-osteocalcin fusion protein and used DE3 (TransGen Biotech, China) to express the reconstructed GluOC. csOCN was purchased from Sangon Biotech, and it is a chemical synthesis of mouse osteocalcin (46 aa) with a C19-C25 disulfide bond modification.

    Techniques: Residue

    CD36 predicted binding affinity for osteocalcin, oleic acid and palmitic acid

    Journal: Journal of Translational Medicine

    Article Title: Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway

    doi: 10.1186/s12967-024-05592-y

    Figure Lengend Snippet: CD36 predicted binding affinity for osteocalcin, oleic acid and palmitic acid

    Article Snippet: We constructed a recombinant mouse GST-osteocalcin fusion protein and used DE3 (TransGen Biotech, China) to express the reconstructed GluOC. csOCN was purchased from Sangon Biotech, and it is a chemical synthesis of mouse osteocalcin (46 aa) with a C19-C25 disulfide bond modification.

    Techniques: Binding Assay

    The colocalization of osteocalcin and CD36. ( A ) GFP fluorescence intensity after lentiviral infection. ( B ) Spatial relationships of lentivirus-infected NCTC 1469 cells treated with rhodamine B-labeled osteocalcin under laser confocal microscopy. ( C ) Spatial relationships of CD36-knockdown NCTC 1469 cells treated with rhodamine B-labeled osteocalcin under laser confocal microscopy. The data are presented as the means ± SD of three independent experiments

    Journal: Journal of Translational Medicine

    Article Title: Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway

    doi: 10.1186/s12967-024-05592-y

    Figure Lengend Snippet: The colocalization of osteocalcin and CD36. ( A ) GFP fluorescence intensity after lentiviral infection. ( B ) Spatial relationships of lentivirus-infected NCTC 1469 cells treated with rhodamine B-labeled osteocalcin under laser confocal microscopy. ( C ) Spatial relationships of CD36-knockdown NCTC 1469 cells treated with rhodamine B-labeled osteocalcin under laser confocal microscopy. The data are presented as the means ± SD of three independent experiments

    Article Snippet: We constructed a recombinant mouse GST-osteocalcin fusion protein and used DE3 (TransGen Biotech, China) to express the reconstructed GluOC. csOCN was purchased from Sangon Biotech, and it is a chemical synthesis of mouse osteocalcin (46 aa) with a C19-C25 disulfide bond modification.

    Techniques: Fluorescence, Infection, Labeling, Confocal Microscopy, Knockdown